1 EU/3/21/2558 Orphan Designation for Treatment Of Glycogen Storage Disease Type Ia
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Glycogen is simply too large a molecule to be launched and journey intercellularly. As well as it seems that glycogen’s role is just not to offer energy substrate purely for astrocytes, thus the trafficking of lactate to neural components makes sense, but does pose just a few important questions. Initial studies by Pierre Magistretti’s group investigated the role of neurotransmitters and different compounds in regulating the glycogen content. They found that glycogen was indeed up- and down regulated by such compounds (Magistretti et al., 1993b, 1994