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 In contrast with mouse thymocytes, mouse ES cells include increased ranges of whole genomic H3K4me3 and have larger H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 forty six In agreement with this, international decreases in H3K4me3 ranges occur during retinoic acid (RA)-induced differentiation of mouse ES cells forty seven In addition, there are dynamic changes in H3K4me3 profiles at particular sets of genes throughout ES cell differentiation.
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